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1.
Arq. Asma, Alerg. Imunol ; 6(4): 483-490, out.dez.2022. ilus
Article in English, Portuguese | LILACS | ID: biblio-1452590

ABSTRACT

Nas últimas décadas tem se observado um aumento expressivo na prevalência de alergia alimentar (AA), com frequência estimada em adultos de 3% a 8%, sendo ainda mais relevante quando se avalia a AA autodeclarada (variação de 3% a 35%). Entretanto, são poucos os dados publicados sobre a prevalência de AA em idosos, e no Brasil tais dados são inexistentes. O objetivo principal deste protocolo de estudo é conhecer a prevalência de AA autodeclarada em idosos (≥ 60 anos) brasileiros. Trata-se de estudo epidemiológico transversal que utiliza questionário padronizado e validado para a língua portuguesa. Entre os vários aspectos investigados, serão avaliados quais alimentos e sintomas são os mais relacionados à AA nestes indivíduos. Os dados obtidos serão transcritos a planilha Excel para realização da análise estatística. A obtenção dessas informações permitirá compará-las às existentes, assim como estabelecer planos de abordagem destes pacientes.


In recent decades, there has been a significant increase in the prevalence of food allergies, reaching an estimated frequency of 3% to 8% in adults and even higher in self-reports (from 3% to 35%). However, published data on the prevalence of food allergies among older adults are scarce, and in Brazil they are non-existent. The main objective of this study was to investigate the prevalence of self-reported food allergy among older Brazilians (≥ 60 years). This cross-sectional epidemiological study protocol involves a questionnaire that was developed, standardized, and validated in Portuguese. The investigated aspects will include the foods and symptoms most commonly associated with food allergy in this population. The data will be input into an Excel spreadsheet for statistical analysis. Obtaining this data will allow comparison of the results with previous data and help establish treatment plans for these patients.


Subject(s)
Humans , Middle Aged , Aged , Aged, 80 and over
2.
Acta odontol. Colomb. (En linea) ; 12(1): 72-79, 2022. ilus 1 Fotografías extraorales de la paciente., ilus 2 Reconstrucción tomográfica tridimensional, ilus 3 Vista axial de estudio tomográfico computarizado de la región palatina del maxilar, ilus 4 Fotografía frontal postoperatoria a un 1 año de evolución
Article in Spanish | LILACS, COLNAL | ID: biblio-1354022

ABSTRACT

Introducción: el síndrome de bandas amnióticas abarca una variedad de anomalías congénitas que incluyen la deformación, disrupción y malformación de múltiples órganos. Este síndrome tiene diferentes manifestaciones clínicas al nacimiento, como anillos formados por la constricción de las bandas, amputaciones de extremidades y malformaciones craneofaciales. La incidencia es de aproximadamente 1 en 1,200-15,000 nacidos vivos. Objetivo: realizar la descripción de un paciente femenino de 4 meses de edad que acude al servicio de cirugía oral y maxilofacial del Hospital del Niño DIF Pachuca, Hidalgo, México. La paciente presenta deformidad en la región geniana que se extiende desde el labio superior hasta la región infraorbitaria de lado derecho, pit paracomisural derecho y fisura Tessier 7. Conclusión: se da el diagnóstico final de deformidad maxilofacial a causa del síndrome de bandas amnióticas y la paciente recibe tratamiento médico-quirúrgico con un resultado satisfactorio.


Backgrond: Amniotic band syndrome encompasses a variety of congenital anomalies which include deformation, disruption, or malformation of multiple organs, exhibiting different clinical manifestations at birth, such as rings formed by the constriction of the bands, limb amputations and craniofacial malformations. The incidence is approximately 1 in 1,200-15,000 live births. Objective: To describe a 4-month-old female patient who attends the oral and maxillofacial surgery service of the Hospital del Niño DIF Pachuca, Hidalgo, Mexico, presenting a deformity in the genian region that extending from the upper lip to the infraorbital region on the right side, right paracommissural pit and Tessier fissure 7. Conclusion: In the final diagnosis of maxillofacial deformity due to amniotic band syndrome, medical-surgical treatment is received with a satisfactory result.


Subject(s)
Humans , Infant , Pediatrics , Amniotic Band Syndrome , Surgery, Oral , Congenital Abnormalities
3.
Braz. dent. sci ; 24(4): 1-7, 2021. tab, graf, ilus
Article in English | LILACS, BBO | ID: biblio-1337600

ABSTRACT

Objective: To determine the prevalence of C-shaped canals in lower molars (first and second molars) in a Chilean subpopulation, and to identify root configuration and demographic characteristics using cone beam tomography.Materials and method: 912 molars (456 first and 456 second molars) resulting from the analysis of 228 mandibular CBCT scans (89 men and 139 women between 15 and 80 years old) were evaluated. Through panoramic reconstruction and axial tomographic sections, the root configuration was established, and the presence and type of C-shaped canal were classified, analyzing 5 levels along the root canal. Data were statistically analyzed with a 5% significance level. Results: Of the 912 molars analyzed, 69 were classified as C-shaped (7.57%), constituting 65.72% of those molars that presented fused roots. 100% of this configuration of canals was observed in lower second molars, presenting a higher prevalence in women (n = 49, 71.01%). 40.82% of the cases that presented a C-shaped configuration manifested bilaterally. The most frequent C-shaped canal configuration was C3 (n = 347, 66.10%), according to Melton's classification. Conclusion: The C-shaped canals in the studied population were observed entirely in lower second molars, showing a clear predilection for the female sex and a high rate of bilaterality (AU)


Objetivo: Determinar a prevalência de canais em forma de C em molares inferiores (primeiros e segundos molares) em uma subpopulação chilena e identificar a configuração radiculares e características demográficas utilizando tomografia feixe cônico. Material e Métodos: Foram avaliados 912 molares ( 456 primeiros e 456 segundos molares) resultando da análise de 228 tomografias de feixe cônico de mandíbulas (89 homens e 139 mulheres entre 15 e 80 anos). Através da reconstrução panorâmica e secções axiais de tomografias, a configuração da raiz foi estabelecida e a classificada a presença e tipo de canal em forma de C, analisando 5 níveis ao longo do canal radicular. Os dados foram analisados estatisticamente com significância de 5%. Resultados: Dos 912 molares analisados, 69 foram classificados como formato de C (7,57%), constituindo 65,72% dos molares que apresentavam raiz fusionadas. 100% dessas configurações de canais foram observados em segundos molares inferiores, com maior prevalência em mulheres (n=49, 71,01%). 40,82% dos casos presentes como formato de C manifestaram-se bilateralmente. A maior frequência das configurações do canal em forma de C no canal foram C3 ( n=347, 66.10%) de acordo com a classificação de Melton. Conclusão: Canais em forma de C no estudo populacional foram observados em sua totalidade nos segundos molares inferiores, demonstrando nítida predileção pelo sexo feminino e alto índice de bilateralidade. (AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Dental Pulp Cavity , Endodontics , Cone-Beam Computed Tomography , Anatomy
4.
Article in Spanish, English | LILACS-Express | LILACS | ID: biblio-1116698

ABSTRACT

La miositis osificante es una rara entidad caracterizada por depósito de hueso heterotópico en tejidos blandos, siendo su principal ubicación el músculo, se han descrito dos variantes: miositis osificante progresiva y miositis osificante traumatica (MOT). El objetivo de este artículo es reportar el primer caso de MOT diagnosticado en México, en paciente femenina de 11 años de edad, quien posterior a enucleación de quiste dentígero desarrolló limitación progresiva a la apertura oral, dolor y trismus, al examen físico sin palpación de masas o deformidades dentro de la cavidad, con apertura oral de 0 mm; en el estudio tomográfico y de reconstrucción se identifica imagen hiperdensa bien definida compatible con calcificación a nivel del músculo pterigoideo medial. Se llevó a resección de lesión, confirmándose diagnostico por histopatología. Paciente actualmente en vigilancia clínica y apoyo con fisioterapia, sin datos de recurrencia.


Myositis ossificans is a rare entity characterized by heterotopic bone deposition in soft tissues, being located mainly in muscle, two variants have been described: progressive myositis ossificans (PMO) and traumatic myositis ossificans (TMO). The objective of this article is to report the first case of TOM diagnosed in Mexico, in an 11-year-old female patient, after enucleation of the dentigerous cyst, developed progressive limitation to the oral opening, pain and trismus, to the physical examination without palpation of mass or deformities within the cavity, with an oral opening of 0 mm; The tomographic and reconstruction study identified a well-defined hyperdense image compatible with calcification at the level of the medial pterygoid muscle. The lesion was resected, confirming the diagnosis by histopathology. Nowadays the patient currently clinical surveillance and physical therapy support, with no recurrence.

5.
Rev. latinoam. psicol ; 52: 235-242, June 2020. tab, graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1251898

ABSTRACT

Resumen La participación cívica es fundamental para abstenerse y sancionar a quienes se benefician de la corrupción. Experimentos muestran que el castigo altruista (pagar para castigar a quienes no cooperan), mantiene cooperando a los transgresores, pero en la vida real se les sanciona poco, siendo necesario identificar los factores que disminuyen esa disposición. Se encuestaron 622 ciudadanos mexicanos, población general, para analizar los efectos de creencias que justifican la corrupción y el apoyo percibido sobre la disposición a actuar contra la corrupción sancionando y absteniéndose de ella. Un modelo de ecuaciones estructurales confirma efectos negativos de las creencias de justificación de la corrupción y positivos del apoyo percibido, además de un efecto negativo indirecto de las creencias de justificación de la corrupción a través de un efecto negativo sobre el apoyo percibido, explicando en conjunto el 47% de la varianza de la disposición a actuar contra la corrupción en un modelo que muestra indicadores que reflejan una adecuada bondad de ajuste.


Abstract Civic participation is essential to abstain and punish the corrupt people. Experimental studies that show altruistic punishment, paying for those who do not cooperate to be punished, keep offenders cooperating, but in real life they are little penalized, being necessary to identify the factors that diminish that disposition. 622 Mexican citizens were surveyed to analyze the effects of beliefs that justify corruption and perceived support on willingness to act against cor ruption by sanctioning and abstaining from it. A model of structural equations confirmed negative effects of corruption justification beliefs and positive perceived support effects, in addition to an indirect negative effect of corruption justification beliefs through a negative effect on perceived support, together explaining for 47% of the variance of the willingness to act against corruption in a model that shows indices of adequate goodness of fit.


Subject(s)
Altruism , Corruption , Punishment , Social Norms
6.
Rev. Méd. Clín. Condes ; 31(2): 174-182, mar.-abr. 2020. tab
Article in Spanish | LILACS | ID: biblio-1223625

ABSTRACT

La comorbilidad entre trastornos del ánimo (TA) y trastornos por uso de sustancias (TUS) es frecuente, empeora el pronóstico de ambos cuadros y dificulta su tratamiento. El reconocimiento y manejo de síntomas anímicos en usuarios de sustancias significa un desafío en la práctica clínica. Si bien existen los trastornos anímicos secundarios a la patología por consumo, la evidencia muestra que la mayor parte de las veces en que ambas patologías coexisten, el trastorno anímico es primario, por lo tanto, el uso de sustancias activo no debiese impedir un tratamiento oportuno del TA, sin descuidar el manejo específico del uso de sustancias, ya que el tratamiento del cuadro afectivo por sí sólo no resuelve el TUS. Existe acuerdo en la necesidad de realizar un tratamiento integrado de ambos trastornos, que incorpore intervenciones farmacológicas y psicoterapéuticas ya validadas para el tratamiento de ambos trastornos por separado, y especialmente aquellas que han mostrado efectividad en la comorbilidad. El tratamiento debe tener un enfoque en la recuperación, que promueva la adherencia y reinserción social. Se requiere mayor investigación sobre el pronóstico y el tratamiento de la comorbilidad entre Trastorno anímicos y por uso de sustancias, y el fortalecimiento de la red de salud general y salud mental en la pesquisa y manejo de estos cuadros.


Comorbidity between Mood Disorders (MD) and Substance Use Disorders (SUD) are common and it worsens the prognosis of both conditions. The recognition and management of mood symptoms in SUD patients is a usual challenge in clinical practice. As opposed to the usual belief, most mood disorders in TUS patients are primary disorders and therefore the use of active substances should not prevent timely treatment of MD, without neglecting the specific management of substance use, since that the treatment of the affective condition alone does not resolve your SUD. There is agreement on the need to perform an integrated treatment of both disorders, which incorporates pharmacological and psychotherapeutic interventions already validated for the treatment of both disorders, and especially those that have shown effectiveness in comorbidity. Treatment should have a focus on recovery, which promotes adherence and social reintegration. More research is required on the prognosis and treatment of comorbidity between mood and substance use disorders, and the strengthening of the general health and mental health network in the research and management of these conditions.


Subject(s)
Humans , Mood Disorders/epidemiology , Substance-Related Disorders/epidemiology , Diagnosis, Dual (Psychiatry) , Mood Disorders/diagnosis , Mood Disorders/therapy , Substance-Related Disorders/diagnosis , Substance-Related Disorders/therapy
7.
Rev. estomatol. Hered ; 25(3): 218-223, jul.-sept. 2015. ilus
Article in Spanish | LILACS, LIPECS | ID: lil-781758

ABSTRACT

Los traumatismos dentales son eventos que suceden frecuentemente. Los datos estadísticos revelan cifras considerables en cuanto a la incidencia y prevalencia de estos accidentes. La intrusión dental es de las más comunes durante la infancia y su tratamiento depende de la severidad del caso. Junto con los traumatismos dentales se presentan lesiones en tejidos blandos, las cuales deben ser tratadas del modo más conservador posible a fi n de reducir las posibles secuelas. Presentación del caso: En el reporte se describe a una paciente femenina de 2 años 8 meses de edad que acude al área de urgencias del Hospital del Niño DIF Hidalgo por presentar ôcaída de las escalerasõ. Acude en primera instancia a otro hospital de donde fue remitida 24 horas después. A la exploración clínica bucal se observa intrusión de dientes 51 y 61. Clínica y radiográficamente apreciamos fractura de tabla alveolar vestibular. Presenta lesión lacerante en encía a nivel de dichos órganos y en el labio inferior. Se realiza lavado de la herida, se extraen los dientes afectados y se suturan las heridas. Se realizó seguimiento a la paciente durante 3 meses observando correcta cicatrización de las heridas. Conclusiones: La paciente presenta una evolución correcta. El manejo oportuno inmediato en este tipo de lesiones es esencial a fi n de disminuir las posibles secuelas...


Dental trauma are events that happen often. Stadistic revels high numbers about incidence and prevalence of these accidents. Dental intrusion is one of the most common injuries among childhood and the treatment de pends of the severity of the case. Dental trauma presents also soft tissue injuries, which must be treated in the most conservative way to reduce possible sequels. Case report: In this paper is described a female patient of two years eight month old which is carried by her mother to the urgency room of the Hospital del Niño DIF Pachuca because she suffered a fell from stairs. She went first to other Hospital and is dispatched to specialized care 24 hours later. At clinical examination we see intrusion of teeth 51 y 61 and lacerating injury of gingiva and lower lip. Clinical and radiographic appreciate fracture of the vestibular alveolar table. The wound is washed, affected tooth are extracted and sutured the injury. We conducted follow-up of the patient for 3 months observing proper healing of wounds. Conclusions: The evolution of the patient was satisfactory. The immediate prompt handling these types of injuries is essential in order to reduce the potential consequences...


Subject(s)
Humans , Child, Preschool , Tooth Injuries , Soft Tissue Injuries
8.
Rev. méd. Chile ; 143(6): 697-706, jun. 2015. ilus, tab
Article in Spanish | LILACS | ID: lil-753509

ABSTRACT

Background: Chronic cocaine users develop multiple potentially lethal ischemic vascular complications associated with accelerated atherosclerosis. Aim: To assess biochemical and lipid profiles among cocaine dependent subjects in recent abstinence. Material and Methods: A blood sample to measure blood count, biochemical and lipid profiles was obtained from 78 patients aged 19 to 53 years (78% males) who complied with DSM-IV criteria for cocaine dependency. Laboratory results were compared with a group of normal subjects. Results: All cases had positive urinary cocaine, with a mean consumption lapse of 7.6 years. The frequency of smoking was higher in cases. Dependent males had higher body mass index than controls. Compared to controls, dependent females had significantly higher triglyceride (TG) levels and lower HDL cholesterol. Therefore the relation total/HDL cholesterol was higher (p = 0.0365). Dependent males had higher TG levels than their normal counterparts. Dependent subjects consuming cocaine base-paste had higher TG levels. Total proteins, albumin, urea and blood urea nitrogen were lower in dependent subjects. Among males, serum creatinine was lower and blood urea was positively correlated with the daily amount of cocaine use (p = 0.03). After a month of strict abstinence, lipid profile was repeated in 27 patients and remained unchanged. Conclusions: Chronic cocaine use was associated with higher TG in both genders and lower HDL cholesterol in women when compared with a group of healthy counterparts.


Subject(s)
Adult , Female , Humans , Male , Middle Aged , Young Adult , Cocaine-Related Disorders/blood , Cocaine/adverse effects , Lipids/blood , Body Mass Index , Cardiovascular Diseases , Cholesterol, HDL/blood , Cholesterol, LDL/blood , Prospective Studies , Sex Factors , Triglycerides/blood
10.
Rev. ing. bioméd ; 4(8): 10-21, jul.-dic. 2010.
Article in Spanish | LILACS | ID: lil-590333

ABSTRACT

Desde sus inicios una de las funciones principales de los ingenieros Biomédicos ha sido garantizar la seguridad del paciente en el entorno clínico por medio de la gestión de la tecnología biomédica y la investigación de incidentes tecnológicos. en la actualidad no es difícil encontrar ingenieros Biomédicos como pieza clave de los equipos interdisciplinarios que analizan eventos adversos en las IPS de Colombia. Aún en contextos tecnológicos, sociodemográficos y regulatorios cambiantes, los Ingenieros Biomédicos han tenido la oportunidad de continuar desarrollando y evolucionando su profesión alrededor de la seguridad del paciente por medio de una variedad de habilidades que incluyen el entrenamiento, evaluación, gestión y diseño de tecnología biomédica. en este proceso ha sido relevante el efectivo trabajo en equipos interdisciplinarios, la colaboración entre entornos hospitalarios y la adecuada transferencia de conocimiento a través agentes de cambio; profesionales que ayudan a educar y difundir nuevas prácticas seguras en la atención en salud. esta entrevista está dedicada a estos profesionales y a la gestión tecnológica y cultural que han emprendido en sus instituciones con el fin de gestionar la seguridad del paciente y mejorar la calidad en la atención en salud; con el resultado de convertirlas en instituciones pioneras en colombia. en este artículo se presentan las opiniones de un grupo de “champions” en seguridad del Paciente sobre el impacto de las políticas gubernamentales, los procesos de análisis de eventos adversos y el papel del ingeniero Biomédico en la seguridad del paciente.


since its conception one of the main functions of Biomedical engineers has been to ensure patient safety in the clinical environment through the management of biomedical technology and the investigation of technological incidents. at present it is not difficult to find Biomedical Engineers as a cornerstone in interdisciplinary teams that analyze adverse events in IPS in colombia. even in changing technological, socio-demographic and regulatory contexts, the Biomedical engineers have had the opportunity to continue developing and evolving their work around patient safety through a diversity of skills including training, assessment, management and design of technology. in this process, the effective interdisciplinary teamwork, the collaboration among health care settings and the proper transfer of knowledge through champions have been important factors. this interview is dedicated to these champions and the technological and cultural management that they have undertaken in their institutions to manage patient safety and increase the quality in health care; with the result of transforming their institutions into pioneers in colombia. this article presents the opinions of a group of patient safety “champions” regarding the impact of government policies, the adverse events process and the role of the Biomedical engineer in patient safety.


Subject(s)
Biomedical Engineering , Equipment Safety , Health Facilities , Colombia
11.
Psiquiatr. salud ment ; 26(3/4): 116-122, jul.-dic. 2009. ilus
Article in Spanish | LILACS | ID: lil-708257

ABSTRACT

Métodos: A partir del año 2007 se efectúan estudios en nuestro Instituto para precisar una dosis adecuada de complejo B a aplicar en el Síndrome de Deprivación Alcohólico (Ibáñez y Bustamante) Resultados: Después de tres semanas de tratamiento con benzodiacepina y complejo B (tiamina) según el nuevo protocolo se logra una recuperación motora y mental de un paciente con un Síndrome Korsakoiwideo alcohólico y un cuadro de paraparesia. Conclusión: Los resultados sugieren que la encefalopatía de Wernicke tratada con dosis superiores a 300 mg/diarios de tiamina puede tener un resultado altamente beneficioso para el paciente con síndrome de deprivación alcohólico.


Method: Since 2007, different studies have been made in our Institute, in order to find the right dose of Vitamin B Complex in cases of Alcohol Withdrawal Syndrome (Ibáñez y Bustamante). Results: After a 3 weeks treatment with Benzodiazepine and Vitamin B Complex (Thiamine), according to the new protocol, a patient with Alcoholic Korsakow Syndrome and Paraparesis, recovers his mental and motor functions. Conclusions: Wernicke’s encephalopathy can be treated with high doses of Thiamine (around 300 mg/a day), on patients with Alcohol Withdrawal Syndrome with highly good results.


Subject(s)
Humans , Male , Middle Aged , Alcoholism/complications , Vitamin B Complex/therapeutic use , Wernicke Encephalopathy/drug therapy , Thiamine/therapeutic use , Alcoholism/drug therapy , Vitamin B Complex/administration & dosage , Substance Withdrawal Syndrome/complications , Substance Withdrawal Syndrome/drug therapy , Treatment Outcome , Thiamine/administration & dosage
13.
Rev. ing. bioméd ; 2(4): 34-45, graf
Article in Spanish | LILACS | ID: lil-773338

ABSTRACT

La adquisición de tecnologías en salud es un proceso complejo enfocado al mejoramiento en la calidad y la eficiencia en la prestación de los servicios de salud a través de la adquisición de tecnología efectiva. Dentro de los procesos de adquisición de tecnologías en salud se destacan la evaluación técnica y clínica. El objetivo de la evaluación de tecnologías en salud es recolectar, analizar y sintetizar información y conocimiento para contribuir a mejorar la toma de decisiones en la práctica médica y en las políticas de salud. Este artículo ofrece un procedimiento de adquisición de tecnología biomédica con énfasis en la evaluación técnica y clínica basado en metodologías de evaluación de tecnologías en salud. También ofrece una estructura detallada sobre los conceptos técnicos y clínicos que servirán de base para la toma de decisiones en procesos de adquisición dentro del ambiente prestador de salud. De igual manera, pretende impulsar en los departamentos de ingeniería clínica la implementación de procesos metodológicos de amplia aceptación y efectividad que tienen como objetivo primordial la adquisición de tecnologías en salud basados en la evidencia. Asimismo, se promueve la participación activa del personal asistencial y técnico con el fin de enfocar el proceso a un ambiente multidisciplinario y obtener retroalimentación específica sobre las tecnologías en salud en áreas de uso a través de usuarios representativos.


The acquisition of healthcare technologies is a complex process focused in the improvement of quality and efficiency in delivering health services through the acquisition of technology in an effective manner. Within the acquisition processes of healthcare technologies, the technical and clinical evaluation highlights. The objective of the health technology assessment is to collect, analyze and synthesize information and knowledge to help improve decision-making in medical practice and health policies. This article provides a procedure for healthcare technologies acquisition with emphasis in technical and clinical evaluation based on health technology assessment methodologies. This presents a detailed structure on technical and clinical concepts that serve as a basis for decision-making procurement processes within healthcare environment. Likewise, it is expected to motivate in clinical engineering departments, the implementation of broad acceptance and effective methodological process that have as its primary objective the acquisition of healthcare technologies based on evidence. It also promotes the active participation of clinical and technical staff in order to approach the process to a multidisciplinary environment and obtain feedback on specific areas of the healthcare technologies trough representative users.

14.
Trastor. ánimo ; 3(2): 137-146, jul.-dic. 2007. tab
Article in Spanish | LILACS | ID: lil-491738

ABSTRACT

We describe a 39-year-old woman with a severe chronic mood disorder, refractory to antidepressive treatment, who showed a marked improvement after a self prescription of very high doses of liothyronine (T3). A modified Refetoff protocol was carried out to study the rol of high doses of thyroid hormones on her clinical and biochemical responses. Depression severity and change was assessed by the HAM-D and MADRS rating scales. Sequencing of thyroid receptors TRalpha1 and TRbeta1 was done and no abnormal findings were obtained. At the final stage of the study plasma T3 and free T3 were >800 ng/dl (80-180) and 1.409 pg/dl (230-420),respectively. No changes in the cardiovascular parameters, alcaline phosphatase isoenzymes or ferritine were observed. An improvement in mood was confirmed by a marhed drop in the rating scales scores (HAM-D 24 to 8; MADRS 40 to 11). These results support the existence in this patient of a peripheral resistance to thyroid hormone (RTH) and the response of depressive symptoms to high dosis of T3 Screening for RTH in refractory chronic depression may pro vide access to alternative and more efficacious treatments for this psychiatric condition.


Describimos el caso de una mujer de 39 años portadora de un trastorno del ánimo crónico y refractario a tratamiento, que experimentó una marcada mejoría de sus síntomas depresivos luego de auto-prescribirse altas dosis de liotiranina (T3). Se le sometió a un protocolo de Refetoff modificado a fin de estudiar los efectos de altas dosis de hormona tiroidea en sus síntomas clínicos y en variables bioquímicas. La severidad y cambio en la intensidad de la depresión se evaluó mediante la aplicación de las escalas HAM-D y MADRS. Se secuenciaron los receptores de hormona tiroidea TRalfa1 y TRbeta1, sin hallazgos anormales. Al final del estudio los niveles plasmáticos de T3 y T31ibre fueron >800 ng/dl (80-180) y 1.409 pg/dl (230-420), respectivamente. No hubo cambios en los parámetros cardiovasculares, fosfatasas alcalinas ni ferritina. Una marcada mejoría del ánimo fue confirmada por la disminución de los puntajes de las escalas aplicadas (HAM-D24 a 8; MADRS 40 a 11). Estos resultados apoyan la existencia de una resistencia periférica a hormona tiroidea (RHT) en esta paciente y la respuesta de los síntomas anímicos a altas dosis de liotironina. La búsqueda de RHT en pacientes con depresión crónica refractaria podría dar acceso a tratamientos alternativos más eficaces para esta condición psiquiátrica.


Subject(s)
Humans , Female , Adult , Depression/drug therapy , Triiodothyronine/pharmacokinetics , Thyroid Hormone Receptors alpha , Thyroid Hormone Receptors beta
15.
CES med ; 21(1): 77-92, ene.-jun. 2007. tab, graf
Article in Spanish | LILACS | ID: lil-472728

ABSTRACT

El propósito de este artículo es realizar una descripción del estado de la técnica en telemedicina a nivel mundial para darla a conocer con profundidad, desde su definición y diferencia con otras áreas similares como telesalud y e-salud. Igualmente se exponen sus objetivos, beneficios, limitaciones, tecnología involucrada y principios de desarrollo. Por ultimo, se describen algunas aplicaclones medicas en telemedicina...


Subject(s)
Educational Technology , Telemedicine , Health Education , Technology
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